General
Preferred name
ZAFIRLUKAST
Synonyms
CPD000466316 ()
ICI 204219 ()
Accolate ()
Vanticon ()
Zafirlukast (ICI-204219) ()
ICI-204219 ()
ICI 204,219 ()
ICI-204,219 ()
P&D ID
PD002945
CAS
107753-78-6
Tags
available
probe
drug
Approved by
FDA
First approval
1996
Drug indication
Asthma
Anti-Asthmatic (leukotriene antagonist)
Drug Status
approved
investigational
Max Phase
4.0
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
High-quality chemical probes
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Zafirlukast is an oral leukotriene receptor antagonist (LTRA), with selectivity for cysteinyl leukotriene receptor 1 (CysLT1 receptor). (GtoPdb)
Cell lines
2
Organisms
3
Compound Sets
37
Bioprocess diversity set
Cayman Chemical Bioactives
10008282
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL603
ChEMBL Drugs
CHEMBL603
Concise Guide to Pharmacology 2017/18
3322
Concise Guide to Pharmacology 2019/20
3322
Concise Guide to Pharmacology 2021/22
3322
Concise Guide to Pharmacology 2023/24
3322
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00549
DrugBank Approved Drugs
DB00549
DrugCentral
2855
DrugCentral Approved Drugs
2855
DrugMAP
DMHNQOG
DrugMAP Approved Drugs
DMHNQOG
DrugMatrix
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
EUB0000407
Guide to Pharmacology
3322
High-quality chemical probes
PD002945
Ki Database
Zafirlukast
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL603
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL603
Mcule NIBR MoA Box Subset
MCULE-2053856450
MedChem Express Bioactive Compound Library
HY-17492
NCATS Inxight Approved Drugs
XZ629S5L50
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
Probe Miner (suitable probes)
Q9Y271/837797
ReFrame library
Selleckchem Bioactive Compound Library
Zafirlukast(Accolate)
TargetMol Bioactive Compound Library
T6736
ZINC Tool Compounds
ZINC000000896717
External IDs
39
Properties
(calculated by RDKit )
Molecular Weight
575.21
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
5
Aromatic Ring Count
4
cLogP
5.7
TPSA
115.73
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.28
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Biological process
Cytokinesis
MOA
Leukotriene Receptor Antagonist
Leukotriene CysLT1 (LTD4) Antagonists
Target
Cysteinyl leukotriene receptor 1
Leukotriene Receptor
CYSLTR1, CYSLTR2
LTR
Member status
member
Indication
asthma
Therapeutic Class
Antiasthmatic Agents
Pathway
GPCR/G protein
Recommended Cell Concentration
None
Source data